Priv.-Doz. Dr. med. J. Packeisen Dr. med. B. Schulte
Priv.-Doz. Dr. med. J. PackeisenDr. med. B. Schulte

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Pathologie OS

Priv.-Doz. Dr. Packeisen

Dr. B. Schulte

Rostocker Strasse 5-7

49124 Georgsmarienhütte

 

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+49 (0)5401 84244-0

Telefax

+49 (0)5401 84244-29

 

Unsere Sprechzeiten

Mo.-Fr. 8.00-17.00 Uhr

Originalarbeiten

 

Salehi M, Schneider L, Ströbel P, Marx A, Packeisen J, Schlücker S. Two-color SERS microscopy for protein co-localization in prostate tissue with primary antibody-protein A/G-gold nanocluster conjugates. Nanoscale. 2014 Feb 21;6(4):2361-7

 

Salehi M, Steinigeweg D, Ströbel P, Marx A, Packeisen J, Schlücker S.: Rapid immuno-SERS microscopy for tissue imaging with single-nanoparticle sensitivity. . J Biophotonics. 2012 Dec 7

 

Liedtke C, Packeisen J, Hess KR, Vogt U, Kiesel L, Kersting C, Korsching E, Brandt B, Buerger H. Systematic analysis of in vitro chemosensitivity and mib-1 expression in molecular breast cancer subtypes. Eur J Cancer 2012 Sep;48(13):2066-74. 

 

Packeisen J, Nakachi K, Boecker W, Brandt B, Buerger H. Cytogenetic differences in breast cancer samples between German and Japanese patients. J Clin Pathol. 2005 Oct;58(10):1101-3.

Packeisen J, Korsching E, Herbst H, Boecker W, Buerger H.: Demystified...tissue microarray technology. Mol Pathol. 2003;56(4):198-204.

 

Stute P, Szuwart T, Schlueter M, Götte M, Packeisen J, Kiesel L. Effects of hormone therapy on estrogen synthesis from E1S in the mammary gland  of postmenopausal women. Maturitas. 2008 Feb 20;59(2):163-73

 

Korsching E, Packeisen J, Böcker W, Bürger H. Bootstrapping algorithm approach reveals inherent regulatory pattern in 550 invasive breast cancer cases: CK 5/6/14 and CK8/18/19 builds an alnagonistic set. Verh Dtsch Ges Pathol. 2005;89:207-10.

 

Kersting C, Packeisen J, Leidinger B, Brandt B, von Wasielewski R, Winkelmann W, van Diest PJ, Gosheger G, Burger H: Pitfalls in immunohistochemical assessment of EGFR- expression in soft tissue sarcomas.J Clin Pathol. 2006
 

Fillies T, Werkmeister R, Packeisen J, Brandt B, Morin P, Weingart D, Joos U, Buerger H. Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity. BMC Cancer. 2006 Jan 13;6(1):10

 

Brandt B, Kemming D, Packeisen J, Simon R, Helms M, Feldmann U, Matuschek A, Kersting C, Hinrichs B, Bidart JM, Bellet D, Bartkowiak K, Dankbar N, Dittmar T, Sauter G, Boecker W, Buerger H.:  Expression of early placenta insulin-like growth factor in breast cancer cells provides an autocrine loop that predominantly enhances invasiveness and motility. Endocr Relat Cancer. 2005 Dec;12(4):823-37.

 

Kersting C, Kuijper A, Schmidt H, Packeisen J, Liedtke C, Tidow N, Gustmann C, Hinrichs B, Wulfing P, Tio J, Boecker W, van Diest P, Brandt B, Buerger H: Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression.Lab Invest. 2006 Jan;86(1):54-61.

 

Korsching E, Packeisen J, Liedtke C, Hungermann D, Wulfing P, van Diest PJ, Brandt B, Boecker W, Buerger H.:The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential? 1: J Pathol. 2005 May 19;

 

Helms MW, Packeisen J, August C, Schittek B, Boecker W, Brandt BH, Buerger H. First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer. J Pathol. 2004 May;203(1):545-50.

 

Buerger H, Packeisen J, Boecker A, Tidow N, Kersting C, Bielawski K, Isola J, Yatabe Y, Nakachi K, Boecker W, Brandt B: Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence--first results of an inter-ethnic breast cancer study. Pathol. 2004 May;203(1):545-50.

 

Korsching E, Packeisen J, Helms MW, Kersting C, Voss R, van Diest PJ, Brandt B, van der Wall E, Boecker W, Burger H: Deciphering a subgroup of breast carcinomas with putative progression of grade during carcinogenesis revealed by comparative genomic hybridisation (CGH) and immunohistochemistry.Br J Cancer. 2004 Apr 5;90(7):1422-8.

 

Muller-Tidow C, Metzelder SK, Buerger H, Packeisen J, Ganser A, Heil G, Kugler K, Adiguzel G, Schwable J, Steffen B, Ludwig WD, Heinecke A, Buchner T, Berdel WE, Serve H. Expression of the p14(ARF) tumor suppressor predicts survival in acute myeloid leukaemia. Leukemia. 2004 Apr;18(4):720-6.

 

Raaphorst FM, Meijer CJ, Fieret E, Blokzijl T, Mommers E, Buerger H, Packeisen J, Sewalt RA, Otte AP, van Diest PJ. Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene. Neoplasia. 2003 Nov-Dec;5(6):481-8.

 

Flohr AM, Rogalla P, Bonk U, Puettmann B, Buerger H, Gohla G, Packeisen J, Wosniok W, Loeschke S, Bullerdiek J. High mobility group protein HMGA1 expression in breast cancer reveals a positive correlation with tumour grade. Histol HistoPathol. 2003;18(4):999-1004.

 

Brandt B, Roetger A, Bidart JM, Packeisen J, Schier K, Mikesch JH, Kemming D, Boecker W, Yu D, Buerger H.: Early placenta insulin-like growth factor (pro-EPIL) is overexpressed and secreted by c-erbB-2-positive cells with high invasion potential. Cancer Res. 2002;62(4):1020-4.

 

Packeisen J, Buerger H, Krech R, Boecker W.: Tissue microarrays: a new approach for quality control in immunohistochemistry. J Clin Pathol. 2002;55(8):613-5.

 

Korsching E, Packeisen J, Agelopoulos K, Eisenacher M, Voss R, Isola J, van Diest PJ, Brandt B, Boecker W, Buerger H.: Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis. Lab Invest. 2002;82(11):1525-33.

 

Packeisen J, Kaup-Franzen C, Knieriem HJ.: Detection of surface antigen 17-1A in breast and colorectal cancer. Hybridoma. 1999 Feb;18(1):37-40.

 

Bonig H, Packeisen J, Rohne B, Hempel L, Hannen M, Klein-Vehne A, Burdach S, Korholz D. Interaction between interleukin 10 and interleukin 6 in human B-cell differentiation.
Immunol Invest. 1998 Jul-Sep;27(4-5):267-80.

 

Körholz D, Hempel L, Packeisen J, Kunst D, Zintl F, Burdach S. [Significance of interleukin 10 for acute graft versus host disease in children and adolescents after allogenic bone marrow transplantation]
Klin Padiatr. 1996 Jul-Aug;208(4):141-4.

 

Kasuistiken:

Packeisen J, Nowak M, Kruger A.: Epulis in a newborn. histogenetic comparison with a granular cell tumor in adults. Pathologe. 2002;23(2):145-8

 

Packeisen J, Klingen D, Grezella F.: Spontaneous rupture of a pancreatic pseudocyst into the portal vein. Z Gastroenterol. 2001;39(11):961-4.

 

Packeisen J, Knieriem H.: Acute appendicitis caused by pregnancy-associated ectopic decidua. Case report and discussion of pathogenesis. Pathologe. 1999;20(6):355-8

 

Abstracts aus wissenschaftlichen Vorträgen und Postern (Auswahl):

 J. Packeisen, C. Liedtke, C. Kersting, B. Brandt, U. Vogt, L. Kiesel, H. Bürger. Chemotherapy response in basal subtyp invasive breast cancer. Results of In-vitro chemosensitivity testing. 91th Meeting of the German Society of Pathology, Margdeburg, Pathol res pract. 2007; 203(5):260

 

J. Packeisen, R. Krech Use of TMA for validation of new assays in immunhistochemistry - quality control in diagnostic pathology 90th Meeting of the German Society of Pathology, Berlin, Pathol res pract. 2006; 202(4):254

 

C. Kersting, J.Packeisen, C. Liedtke, B.Brandt, P. Wülfing, C. Gustmann, B. Hinrichs, W. Böcker, H. Bürger. Immunhistochemical evaluation of EGFR dependent pathway in phylloides tumors of the breast. 90th Meeting of the German Society of Pathology, Berlin, Pathol res pract. 2006; 202(4):238

 

Packeisen J, Vogt U, vd Assen A, Krech RH, Böckere W, Bürger H: Correlation of intermediate filament expression and in vitro chemosensitivity of primary invasive breast cancer. 89 th  Meeting of the German Society of Pathology, Wuppertal, Pathol res pract. 2005; 201(3):293

 

Kersting C, Packeisen J, Leidinger B, Brandt B, v. Wasielewski R, Winkelmann W, Gosheger G, Böcker W, Bürger H: Correlations of clinico-pathological features with epidermal growth factor receptor (EGFR) overexpression in soft tissue sarcomas are antibody-dependent. 89 th  Meeting of the German Society of Pathology, Wuppertal, Pathol res pract. 2005; 201(3):200

 

August C, Alberty J, Packeisen J, Tappe H, Bürger H, Hungermann D, Böcker W, Korsching E: Biomathemathical cluster analysis of immunohistochemical results on a tissue microarray of 57 malignant salivary gland tumors: The importance of a new method in stem cell concept of tomorgenesis. 89 th  Meeting of the German Society of Pathology, Wuppertal, Pathol res pract. 2005;201(3):284

 

Korsching E, Packeisen J, Voss R, Böcker W, Bürger H: Bootstrapping approach reveals inherent regulatory pattern in 550 breast cancer cases: CK5/6 CK14 and CK8/18 CK19 builds an antagonistic set. 89 th  Meeting of the German Society of Pathology, Wuppertal, Pathol res pract. 2005; 201(3):161

 

Bürger H, Korsching E, Packeisen J, Hungermann D, Liedtke D, Decker T, Böcker W: Orgin of vimentin expression in invasive breast cancer: Epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential? 89 th  Meeting of the German Society of Pathology, Wuppertal, Pathol res pract. 2005; 201(3):171

 

Packeisen J, Thebing-Barrier U, Bürger H, Böcker W, Krech RH: Tissue microarray for quality control in immunohistochemistry – experience and possibilities. 89 th  Meeting of the German Society of Pathology, Wuppertal, Pathol res pract. 2005; 201(3):201

 

Kersting C, Packeisen J, Liedtke C, Brandt B, Wülfing P, Gustmann C, Hinrichs B, Böcker W, Bürger H: Epidermal growth factor receptor (EGFR) expression and egfr gene dosage measurement in phyllodes tumors of the breast. 89 th  Meeting of the German Society of Pathology, Wuppertal, Pathol res pract. 2005; 201(3):292

 

Bürger H, Helms M, Packeisen J, August C, Brandt B, Böcker W: The BMPR/SMAD pathway is involved in dedifferentiation and progression of oestrogen receptor positive breast cancer. 89 th  Meeting of the German Society of Pathology, Wuppertal, Pathol res pract. 2005; 201(3):295

 

Vogt U, v.d.Assen A, Packeisen J, Gregorowicz K, Bielawski K: Correlation of selected molecular markers to in vitro chemo sensitivity of node-negative primary human breast cancer.ASCO Annual Meeting 2004

 

Packeisen J, Leidinger B, Liedtke C, Rödl R, Winkelmann W, Gosheger G, Bürger H.: 88 th  Meeting of the German Society of Pathology, Rostock, Pathol res pract. 2004;200 (4):243

 

Packeisen J, Fillies T, Brandt B, Werkmeister R, Joos U, Böcker W, Bürger H.: 88 th  Meeting of the German Society of Pathology, Rostock, Pathol res pact. 2004;200 (4):243

 

Packeisen J, Korsching E, Liedtke C, Kemming D, Brandt B, Böcker W, Bürger H.: 88 th  Meeting of the German Society of Pathology, Rostock, Pathol res pract. 2004;200 (4):243

 

Brandt B, Packeisen J, Kemming D, Simon R, Bidart JM, Buerger H: Early placenta insulin-like growth factor (EPIL) indicates highly motile breast cancer cells and poor prognostic Her2-positive and Her-2negative subgroups of breast cancer. ASCO 2003

 

Packeisen J, Krech R, Böcker W, Bürger H.: Multi-tissue microarrays - a new approach for quality control in immunohistchemistry. 86 th  Meeting of the German Society of Pathology, Wien, Pathol res pract. 2002;198 (4):214

 

Packeisen J, Bürger H, Korsching E, Eisenacher M, van diest PJ, Brandt B, Krech R, Böcker W. Tissue microarrays (TMA´s) as a new tool in experimental Pathology. J Pathol 2002, 198(Suppl):2A

 

CH. Kaup-Franzen, J. Packeisen, H.J. Knieriem: Nachweis disseminierter Tumorzellen im Knochenmark im Vergleich zu anderen Prognosefaktoren. Pathologe 2000, 21;278

 

CH. Kaup-Franzen, J. Packeisen, H.J. Knieriem: Nachweis des 17-1A Antigens in Primärtumoren von Kolon-, Mamma-, Magen-, Lungen- und Prostatakarzinomen. Pathologe 1999, 20;138.

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